Your brain stays well with the help of a strong wall called the blood-brain barrier (BBB). But as you get older, this wall gets weak, raising the chance of brain troubles like Alzheimer's or stroke. Two things from nature, Fisetin and Spermidine, might keep and help your brain stay well in their own ways:
- Fisetin: In strawberries, apples, and onions, it goes through the BBB and takes out old cells, cuts down swelling, and helps brain work.
- Spermidine: In wheat germ, cheese, and mushrooms, it helps clean up cells, cuts waste and swelling, and makes your body work better.
Quick Look
| Aspect | Fisetin | Spermidine |
|---|---|---|
| How it works | Takes out old cells, cuts harm | Ups clean-up, cuts left stuff |
| BBB Access | Goes right through the BBB | Can get in, but not as clear |
| Research Evidence | Good tests in animals | Mix of human results |
| Food Sources | Strawberries, apples, onions | Wheat germ, cheese, mushrooms |
| Dosage | ~500 mg/day (from pills) | ~6–10 mg/day (from food or pills) |
Both parts are good in their own way: Fisetin guards the brain, while Spermidine helps all cells stay well. To get the best out of them, talk to a doctor before you start any new pills.
Benefits Of Spermidine On Brain Health
1. Fisetin
Fisetin is a type of natural stuff found in strawberries, apples, and onions. It's cool because it can go through the wall that guards the brain, helping it support the brain directly.
How It Works
Fisetin helps keep the brain well by hitting and clearing out old cells - these are the cells that build up as you age. By getting rid of these, fisetin might help make new cells, which is key to making sure your brain stays sharp.
Effects on the Brain Wall
Studies say fisetin moves fast into the brain after you eat it [3][4]. For example, tests on mice showed that fisetin gets deep into the brain, with rates of 7.8% at a 100 mg/kg dose and 31.7% at a 200 mg/kg dose [3]. It also helps the part of the brain called the hippocampus work better, which shows it could help the brain in many ways [3].
Research Evidence
In tests, people often get fisetin in doses now and then, a style known as "hit and run" [5]. In experiments on people, they usually take about 20 mg per kilo of weight [5]. A cool test on rats checked ten plant bits and found fisetin did better than well-known ones like resveratrol, quercetin, and curcumin [5]. This info helps guide the best way to use it.
Dosage Guidelines
MASI Premium Fisetin has 500 mg per pill. For those 40–50 years old, you take one pill a day, and if you're over 50, you take two a day. For the best outcome, mix the pill with healthy fats to help your body take it in better.
2. Spermidine
Spermidine is a simple, natural thing often seen in foods such as wheat germ, old cheese, mushrooms, soybeans, and things that have fermented. It helps cells grow and fix themselves and can go into the brain from the blood, which is good for keeping the brain well. Let's look at how spermidine does its job and what studies show about its results.
"Spermidine is part of a family of compounds called polyamines that play a big role in how our cells grow and repair themselves."
– Georgia Pilling, BSc, Physiological Sciences; MRes, Neuroscience, Oxford Healthspan [7]
How It Works
Spermidine plays a big part in a clean-up act our bodies do called autophagy. It's how our bodies get rid of bad proteins and cell waste, which cuts down swelling in the brain. It also turns on paths in parts of the brain linked to memory, making more energy and better work there.
Effects on the Blood–Brain Barrier
A big thing about spermidine is that it can move through the blood–brain barrier. In mouse tests, food-based spermidine made important parts of the memory area of the brain work. But when things go wrong in the body, it may make this barrier more open. This shows that what it does might change with the brain’s health [7][8].
Research Evidence
Tests on animals show spermidine might help with map learning and using oxygen in cells. Yet, human tests have had mixed results. For example, in the SmartAge trial with 100 older people, ages 60–90, they took 0.9 mg of spermidine each day. They saw no key changes in memory tests, but other looks hinted it might help with word memory and lessen swelling [6][9].
"In this randomized clinical trial, longer-term spermidine supplementation in participants with subjective cognitive decline did not modify memory and biomarkers compared with placebo. Exploratory analyses indicated possible beneficial effects on verbal memory and inflammation that need to be validated in future studies at higher dosage."
– Claudia Schwarz, PhD, Department of Neurology, Charité–Universitätsmedizin Berlin [9]
It's good to know that high spermidine levels can be risky. One study showed that people with levels at 205.9 nmol/L or more had higher chances of having a stroke (hazard ratio 5.02, 95% CI 1.58–16.02) than those with lower levels.
Dosage Guidelines
Picking the right amount is key to get the most from spermidine. Usual doses are from 6 mg to 10 mg each day, and many think 10 mg is best. Studies show that even small amounts, like 0.9 mg daily with other polyamines, can help your mind work better. In Europe, people often get 10–15 mg of spermidine in their food each day. Taking 10 mg each day can also help with waist size, BMI, and blood sugar levels.
If you want a steady dose, MASI Premium Spermidine is an easy choice. But, it’s smart to talk to a doctor before you start any new supplement, especially if you are pregnant, breastfeeding, or taking other meds.
While fisetin cleans cells directly, spermidine works differently by making the brain stronger through autophagy and bettering metabolism. They both have their own ways to help keep you healthy for a long time.
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Advantages and Disadvantages
Fisetin and spermidine are both good for brain help, but they work in different ways and have different results.
| Aspect | Fisetin | Spermidine |
|---|---|---|
| Blood-Brain Barrier Access | Good in getting through – Goes into the body well when eaten, and reaches the brain well [1] | Hard to get through – It's not sure if it can go into the brain well, and too much might cause problems [2] |
| Antioxidant Properties | Strong shield – Fights off harm-causers and helps body's own guard cells [1] | Okay shield – Works by holding onto metals to stop harm [11] |
| Research Evidence | Good animal tests – Tests on animals show it could protect the brain and help with thinking | Mixed in people – A study with 100 people for a year did not show better memory [9] |
| Safety Profile | Possible bad effects – Might upset stomach or cause stomach pain or loose bowels if you haven't eaten; too much might hurt liver [12] | Worries with too much – High levels in blood may show the brain is getting old [2] |
| Bioavailability | Available in foods – In strawberries (160 μg/g), but you might need more from pills for real help [10] | Easy to get from diet – In wheat germ, old cheese, and foods that rot a bit, so it's easy to eat enough |
These checks are on new study, showing a real look at each mix.
Fisetin's way to get into the brain is key. For instance, in tests where the brain stops working right, amounts of 25–50 mg/kg almost kept safe a key brain protein [1]. This skill makes fisetin good for right on brain help.
Yet, spermidine is good at cell care. It helps a clean-up of bad cell parts - but its direct brain effects are not sure. The SmartAge test, from January 2017 to May 2020, saw no big brain memory boosts with a daily 0.9 mg over 12 months against a fake drug [9].
Both mixes need smart thinking on how much to use. Fisetin is best with food to cut belly upset, while you must watch how much spermidine is in the blood to stop bad results. While fisetin seems better for brain help, spermidine helps all cell health.
These facts show why MASI puts a lot of thought into how to mix stuff for the best brain health gains.
Wrap-Up
Fisetin and spermidine both help brain health, which makes them a good pair for thinking well. Fisetin is good as it can get into the brain fast and keep it safe with its antioxidant and anti-swelling actions. On the other side, spermidine helps clean up cells by driving autophagy, getting rid of bad parts. While fisetin can get into the brain well, we are not sure if spermidine can do the same [2].
If you want to keep your brain safe right away, fisetin seems like a good pick. The amount we get from food is only 0.4 mg a day – much less than what studies show works – so you might need more from a supplement [1]. Spermidine, on the other hand, is about 6 mg a day, and helps keep cells all over in good shape. You can eat more foods like wheat germ, soybeans, and shiitake mushrooms or pick a supplement. Still, we need more big studies to really see if spermidine helps memory when you add more [2].
Together, these things help in different ways. Fisetin works now by going after old cells, and spermidine helps keep cells well for a long time by boosting autophagy. Starting with small amounts of each is smart, and you should always talk to a health expert before you start any new supplement plan.
Keeping your brain well is a big task that needs a good plan. MASI Longevity Science is good at making exact mixes and dosing plans to get the most out of these things while keeping it safe. By using both fisetin's safe actions and spermidine's cell help, you can work on two parts at once to keep your brain well as you get older.
FAQs
How can Spermidine help keep the brain well, and who may need it most?
Spermidine may be good for brain health, mostly for old people. Some early work shows it might help with brain power and keep brain cells safe, mainly in those who are losing memory due to age or might get brain diseases.
Old people who are just starting to face memory problems or are less sharp may get the most from taking Spermidine. But, as the study on it is still going on, it's key to talk to a doctor before using it. This makes sure it fits well with your own health plans and aims.
