NMN (nicotinamide mononucleotide) is a molecule that helps increase NAD⁺ levels in the body, which are essential for energy production, DNA repair, and managing oxidative stress caused by reactive oxygen species (ROS). As we age, NAD⁺ levels naturally decline, leading to weaker cellular defenses and mitochondrial dysfunction, especially in high-energy organs like the brain. Supplementing with NMN has been shown to restore NAD⁺ levels, improve mitochondrial health, and reduce oxidative damage.
Key takeaways:
- NMN boosts NAD⁺: Supports energy production and activates protective enzymes like SIRT3.
- ROS and oxidative stress: Excess ROS damage proteins, lipids, and DNA, contributing to aging and diseases like Alzheimer's.
- Cellular and brain health: NMN helps protect mitochondria, reduce ROS, and improve blood vessel function, benefiting brain and vascular health.
- Research findings: Animal studies show NMN improves cognitive function, reduces inflammation, and protects neurons from damage.
MASI Longevity Science produces NMN supplements with strict quality testing, focusing on cellular health and aging. Their products aim to support mitochondrial function and reduce oxidative stress, with a growing global community relying on their solutions.
How NMN Protects Cells
Boosting NAD⁺ Levels to Fight ROS
When NMN enters cells, it increases mitochondrial NAD⁺ levels, which plays a critical role in defending against reactive oxygen species (ROS). This is especially important for mitochondria that are already under stress. For instance, a single 62.5 mg/kg dose of NMN in male mice significantly elevated hippocampal mitochondrial NAD⁺ levels for up to 24 hours [1]. This sustained increase equips cells with the tools they need to combat oxidative stress effectively.
The mechanism hinges on the activation of SIRT3, an enzyme that safeguards mitochondria. As NAD⁺ levels rise, SIRT3 becomes more active, leading to the deacetylation of mitochondrial proteins. Research shows that NMN reduces mitochondrial protein acetylation by about 40% at various intervals after injection [1]. One critical protein affected is manganese superoxide dismutase (SOD2), an antioxidant enzyme. Deacetylation of SOD2 by SIRT3 enhances its ability to neutralize harmful ROS. Remarkably, just one hour after NMN administration, SOD2 acetylation drops by 30% compared to control samples [1]. This improvement in mitochondrial function helps limit the production of additional ROS.
"Manipulation of mitochondrial NAD+ levels by NMN results in metabolic changes that protect mitochondria against reactive oxygen species and excessive fragmentation, offering therapeutic approaches for pathophysiologic stress conditions." - Nina Klimova et al. [1]
Lowering Mitochondrial ROS Production
NMN tackles ROS production at its source by ensuring mitochondria maintain sufficient NAD⁺ levels for efficient energy production, minimizing harmful byproducts. It also prevents excessive mitochondrial fission by lowering levels of mitochondrial pDrp1 (S616), which helps maintain mitochondrial structure [1]. Beyond this, NMN activates SIRT1, which boosts the expression of antioxidant enzymes. For example, in studies involving human umbilical vein endothelial cells (HUVECs), NMN reduced oxidative stress by increasing the expression of NAD(P)H: quinone oxidoreductase 1 (NQO-1) via SIRT1 activation [2]. By addressing ROS directly within mitochondria, NMN not only shields cells but also supports vascular and brain health.
Improving Blood Vessel and Brain Health
The brain, with its high energy and oxygen demands, is particularly vulnerable to damage from ROS. NMN helps protect brain health by improving blood vessel function, which enhances the delivery of oxygen and nutrients. In cardiovascular studies, NMN supplementation restored vascular function and elevated NAD⁺ levels in aged mice [3].
These vascular benefits translate directly to better brain function. A study published in Redox Biology demonstrated that 24-month-old C57BL/6 mice treated with NMN for two weeks experienced improved neurovascular coupling responses. This was achieved through enhanced endothelial nitric oxide-mediated vasodilation, leading to notable improvements in spatial working memory and gait coordination [4]. By restoring nitric oxide signaling and improving blood flow, NMN ensures brain cells receive the oxygen and nutrients they need to function at their best and resist age-related decline.
Research on NMN and Brain Disease
Results from Animal Studies
Animal studies have provided compelling evidence of NMN's role in supporting brain health. In one study, aged mice treated with NMN for 14 days experienced restored cerebral blood flow and improved neurovascular coupling, bringing these functions back to levels typically seen in younger mice. Similarly, a D-galactose aging model revealed several benefits, including improved cognitive performance, reduced inflammation, enhanced mitochondrial function, and lower oxidative stress [5][6]. NMN also increased NAD⁺ levels in the brains of these mice by 2.04 times, bolstering cellular energy production and improving neuronal function [7].
Effects on Alzheimer's Disease
Research into NMN's effects on Alzheimer's disease has shown promising outcomes in animal models. For instance, in mice injected with amyloid β, a hallmark of Alzheimer's, NMN supplementation improved spatial working memory, as seen in higher spontaneous alternation rates during Y-maze tests [8]. Beyond cognitive improvements, NMN treatment led to larger hippocampal CA1/CA3 neuron areas, indicating protection against neuronal damage. High doses of NMN also reduced malondialdehyde levels, a marker of oxidative stress, in the brains of these mice. Additional findings included reduced p-tau levels in both the cortex and hippocampus, enhanced autophagy, and modulation of the Nrf2/Keap1/NQO1 pathway [8]. These results highlight NMN's potential in addressing Alzheimer's-related brain changes and restoring cellular energy balance.
Restoring NAD⁺ and Cellular Energy
Declining hippocampal NAD⁺ levels - nearly 40% lower in 10- to 12-month-old mice compared to 1-month-old counterparts - are closely linked to mitochondrial dysfunction and cognitive decline [9]. NMN treatment has been shown to reverse this decline, boosting NAD⁺ levels more than threefold, from 500 to 1,550 pmol/mg-tissue, and increasing mitochondrial NAD⁺ levels from 3.12 to 5.51 nmol/mg [10]. This increase activates SIRT3, leading to reduced mitochondrial protein acetylation and improved metabolic function. In Alzheimer's disease model rats, NMN supplementation not only restored learning and cognition but also enhanced energy metabolism, reduced oxidative stress, and improved behavioral outcomes. These studies also noted reductions in Alzheimer's-associated pathological markers [10]. By replenishing NAD⁺ levels, NMN helps reestablish energy metabolism and fortifies cellular defenses against neurodegenerative processes.
The MASI Longevity Science Advantage
High-Quality Standards and Rigorous Testing
MASI Longevity Science prioritizes pharmaceutical-grade materials and strict quality control measures. Each NMN supplement is crafted in Germany using premium ingredients and undergoes independent testing in Switzerland to ensure purity, safety, and effectiveness. This thorough process guarantees that every batch meets stringent international standards before reaching consumers.
Transparency is a cornerstone of MASI's approach. The company provides detailed insights into its sourcing, manufacturing, and testing procedures. By incorporating third-party verification, MASI reinforces its evidence-based commitment to cellular health and healthy aging. This meticulous attention to quality forms the backbone of its efforts to enhance mitochondrial function and combat oxidative stress.
Supporting Mitochondrial Health and Combating Oxidative Stress
MASI's NMN supplements are designed to target two major factors of cellular aging: mitochondrial dysfunction and reactive oxygen species (ROS). The formulation enhances the activity of key enzymes like catalase (CAT) and superoxide dismutase (SOD), which play vital roles in reducing ROS levels and minimizing oxidative damage to cells [12].
Additionally, MASI's supplements promote the upregulation of protective proteins such as heme oxygenase-1 (HO-1). This enzyme is crucial for its antioxidant properties and neuroprotective effects under oxidative stress [11]. Beyond NMN, MASI offers a range of supplements like Resveratrol, Fisetin, and Spermidine, each addressing specific aspects of aging, including mitochondrial dysfunction, oxidative stress, cellular senescence, and inflammation. Together, these products support cellular renewal, heart and brain health, and long-term vitality.
This targeted approach to cellular health has earned MASI the trust of a growing global community.
A Global Community Backing MASI
More than 352,000 people worldwide rely on MASI products to support their vitality and cellular health. This dedicated community provides valuable feedback and shares experiences, helping MASI refine its products to meet practical needs.
MASI's reputation rests on its scientific rigor and commitment to transparency. The company shares independent lab results and comprehensive product documentation, ensuring users can trust the science behind NMN and its role in cellular protection. Moreover, MASI's products are vegan-friendly and free from GMOs, soy, lactose, gluten, and common allergens.
For U.S. customers, MASI adapts product details to align with local standards, including currency, measurements, and labeling. Flexible subscription plans make it easy to maintain access to these supplements, with options ranging from monthly deliveries with a 5% discount to annual subscriptions offering a 15% discount.
sbb-itb-4f17e23
'Address brain aging and push back cognitive decline'
Conclusion: NMN's Potential for Cellular Protection
Research highlights NMN's ability to address mitochondrial dysfunction and oxidative stress - two major contributors to cellular aging.
In animal studies, NMN treatment significantly reduced oxidative stress markers. For instance, protein carbonyl content in stressed retinas dropped from 0.81 ± 0.1 nmol/mg to 0.55 ± 0.15 nmol/mg after NMN treatment[11]. This reduction in oxidative damage showcases NMN's promise in protecting cells from stress-related harm.
NMN also supports mitochondrial health by increasing NAD⁺ levels, which play a key role in DNA repair and activating antioxidant enzymes like catalase, SOD, and HO-1. Together, these mechanisms create a strong defense against cellular damage[11][12].
Additionally, animal research reveals NMN's ability to shield neural cells from ROS-induced damage through SIRT1 and HO-1 pathways. This suggests potential benefits for brain health and reducing age-related cognitive decline[11].
These findings align with the high standards upheld by MASI Longevity Science. Manufactured in Germany under pharmaceutical-grade conditions and independently tested in Switzerland, MASI's products aim to deliver the cellular protection reflected in research. With over 352,000 people worldwide incorporating MASI's science-based solutions into their longevity plans, NMN continues to gain recognition as a promising tool for healthy aging.
FAQs
How does NMN support mitochondrial health and reduce oxidative stress?
NMN plays a crucial role in improving mitochondrial health by activating sirtuins, especially Sirt3. These proteins are essential for regulating mitochondrial function and reducing oxidative stress. By supporting oxidative phosphorylation, NMN helps cells produce energy more effectively and minimizes mitochondrial damage caused by reactive oxygen species (ROS).
In aging tissues, including the brain, NMN enhances mitochondrial efficiency by triggering pathways that fight ROS. This dual action not only shields cells from oxidative damage but also strengthens their resilience. Such cellular support is critical for preserving brain health and combating age-related neurodegenerative issues.
How does NMN supplementation support brain health and cognitive function?
NMN supplements have been linked to supporting brain health and cognitive function by tackling neuroinflammation, shielding neurons, and improving how mitochondria work. These effects can help slow down cognitive decline, support the survival of neurons, and enhance neurovascular responses - key factors in addressing age-related conditions like Alzheimer’s disease.
By increasing NAD+ levels, NMN contributes to cellular energy production and DNA repair, both essential for maintaining mental sharpness and long-term brain health. These outcomes reflect MASI Longevity Science’s dedication to creating scientifically backed solutions that promote brain vitality and cognitive well-being.
How does MASI Longevity Science ensure the quality and safety of their NMN supplements?
MASI Longevity Science prioritizes quality and safety in their NMN supplements by strictly following Good Manufacturing Practices (GMP) and subjecting each batch to thorough independent third-party testing in Switzerland. These tests are essential for confirming the purity, safety, and reliability of their products.
To guarantee top-tier standards, MASI employs high-performance liquid chromatography (HPLC) to accurately measure the concentration and purity of their NMN. Every step of their process is crafted to provide supplements you can rely on to support cellular health and promote longevity.
