Sirtuins are proteins that help repair cells, regulate metabolism, and potentially slow aging. Supplements like NMN, Resveratrol, Fisetin, and Spermidine activate sirtuins, supporting energy production, DNA repair, and overall cellular health. Here's what you need to know:
- Why Sirtuins Matter: They protect DNA, improve energy metabolism, and support brain and heart health.
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Key Supplements:
- NMN: Boosts NAD⁺ levels, essential for sirtuin function.
- Resveratrol: Activates SIRT1 and supports heart health.
- Spermidine: Promotes autophagy and cellular renewal.
- Fisetin: Reduces inflammation and clears senescent cells.
- Dosage Tips: NMN (250–1,200 mg/day), Resveratrol (100–500 mg/day), Spermidine (5–10 mg/day), Fisetin (100–500 mg/day).
Quick Overview of Benefits
| Supplement | Key Benefits | Recommended Dosage |
|---|---|---|
| NMN | Energy metabolism, DNA repair | 250–1,200 mg/day |
| Resveratrol | Heart health, sirtuin activation | 100–500 mg/day |
| Spermidine | Cellular renewal, autophagy | 5–10 mg/day |
| Fisetin | Inflammation reduction, cognitive health | 100–500 mg/day |
Sirtuin supplements work best when paired with healthy habits like exercise, intermittent fasting, and a nutrient-rich diet. Keep reading for a deeper dive into how these supplements can support longevity and cellular health.
#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
Main Sirtuin-Activating Compounds
Researchers have identified several compounds that boost sirtuin activity, each working through distinct biological pathways.
Resveratrol's Role
Resveratrol has been shown to activate SIRT1, increasing its enzymatic activity up to tenfold via an allosteric mechanism [4]. This compound is also linked to cardiovascular benefits, such as improved coronary relaxation, fewer ventricular arrhythmias, better glucose metabolism, and healthier cholesterol levels [5].
NMN and NAD+ Levels
Nicotinamide Mononucleotide (NMN) acts as a direct building block for NAD+, a critical cofactor needed by sirtuins. By middle age, NAD+ levels can drop to nearly half of youthful levels, negatively affecting cellular energy production [8]. Supplementing with NMN helps counteract this decline, supporting various bodily functions, including metabolism, brain health, and inflammation control. Here's a quick overview of NMN's observed benefits:
| Benefit | Observed Effect |
|---|---|
| Metabolic Support | Enhanced insulin secretion and action |
| Cellular Energy | Improved mitochondrial function |
| Brain Health | Enhanced neuronal function |
| Inflammation | Reduced age-related adipose inflammation |
(Source: [8])
Fisetin and Spermidine Benefits
Fisetin is known for its ability to clear senescent cells, while spermidine promotes autophagy. Remarkably, spermidine is the only polyamine consistently linked to lifespan extension across various organisms, from yeast to mice [7]. It also supports mitochondrial health, reduces inflammation, and protects stem cells [6]. MASI incorporates such findings into its supplements, which adhere to strict Swiss testing standards, reflecting its commitment to science-driven formulations.
Sirtuin Activation Health Effects
Cell Repair and DNA Protection
Sirtuins are essential for maintaining cellular health, particularly under stress. They respond to oxidative and genotoxic stress by enhancing DNA repair mechanisms [3]. These proteins protect the genome by regulating the cell cycle during damage response, reshaping chromatin to allow repair proteins better access, and directly influencing the activity of these repair proteins [9]. For instance, when SIRT7 levels drop, mutation rates increase [9]. Similarly, studies on mouse embryonic fibroblasts show that the absence of SIRT1 hinders DNA repair following radiation exposure [10]. These protective roles underline how sirtuins also contribute to metabolic regulation.
Metabolism and Energy Benefits
Sirtuins play a key role in energy metabolism, particularly during low-energy states like fasting or exercise [2]. They influence various tissues and processes, as outlined below:
| Tissue | Sirtuin Effects |
|---|---|
| Liver | Encourages gluconeogenesis and fatty acid oxidation |
| White Adipose | Decreases fat storage and limits adipogenesis |
| Brown Adipose | Boosts mitochondrial activity |
| Pancreas | Improves insulin secretion |
| Skeletal Muscle | Enhances mitochondrial function and insulin sensitivity |
These effects help maintain energy balance as we age [11]. By regulating metabolism, sirtuins also lay the groundwork for benefits to brain and heart health.
Brain and Heart Protection
Beyond metabolism, sirtuin activation offers protection for vital organs like the brain and heart. In the brain, activating SIRT1 reduces harmful protein buildup and inflammation, which are linked to neurodegenerative conditions [1]. In the cardiovascular system, sirtuins prevent foam cell formation, aid vascular repair, and may help reduce cardiac hypertrophy [1]. These actions support neural health and vascular repair, helping to mitigate age-related declines in brain function and maintain heart health as we grow older.
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Using Sirtuin Supplements
To make the most of sirtuin supplements, it’s essential to understand how to use them effectively. Proper dosage, smart combinations, and supportive habits all play a role in achieving the best results.
Dosage Guidelines
Getting the dosage and timing right is critical for activating sirtuins. Research suggests that higher doses of NMN, such as 1,200 mg, can significantly boost aerobic performance in amateur runners, compared to lower doses like 300 mg [13]. Similarly, studies with Japanese men have shown that NMN doses ranging from 100 mg to 500 mg lead to measurable increases in NAD⁺ metabolites [12].
| Compound | Daily Dosage Range | Timing |
|---|---|---|
| NMN | 250–1,200 mg | Morning, any food state |
| Resveratrol | 100–500 mg | Morning, with fatty foods |
| Fisetin | 100–500 mg | With meals for better absorption |
| Spermidine | 5–10 mg | Any time of day |
Next up: how combining these supplements can amplify their effects.
Supplement Combinations
Using a combination of NMN, Resveratrol, Spermidine, and Fisetin can deliver powerful, synergistic benefits for longevity. Each compound plays a unique role in targeting key pathways that support healthy aging:
- Core function: NMN boosts NAD⁺ production, a critical factor for energy and cellular health.
- Improved sensitivity: Resveratrol enhances how effectively sirtuins respond.
- Added support: Spermidine and Fisetin contribute extra protection at the cellular level.
"Combining NMN with compounds like Resveratrol, Spermidine, and Fisetin offers a comprehensive approach to longevity by providing synergistic benefits. This combination enhances mitochondrial function, reduces oxidative stress, and improves insulin sensitivity for a holistic anti-aging effect." [14]
Supporting Habits
Supplements are just one piece of the puzzle. Incorporating supportive habits into your daily routine can further activate sirtuins and optimize their effects.
Dr. Mark Hyman highlights: "Sirtuins are a great example of the emerging knowledge that can help us age optimally. These are proteins that can prevent disease and even reverse the signs of aging. What's really cool is that sirtuins can be activated by certain compounds like resveratrol and NAD that we can get through certain foods or supplements." [16]
Here’s how you can integrate lifestyle practices to complement your supplementation:
Exercise Protocol
- Prioritize endurance training [17].
- Keep up with regular aerobic exercises [17].
- Add moderate sports activities to your routine [18].
Dietary Practices
- Experiment with intermittent fasting [18].
- Include foods known to activate sirtuins, such as berries, nuts, and olive oil [15].
- Consider caloric restriction when appropriate [18].
Daily Habits
- Stick to consistent sleep–wake cycles.
- Stay well-hydrated throughout the day [15].
- Regularly evaluate and fine-tune your regimen for the best results.
MASI Longevity Science Products
MASI takes the science of sirtuin mechanisms and transforms it into practical solutions aimed at supporting longevity. Their supplements are designed to activate sirtuins, combining cutting-edge research with reliable manufacturing practices to provide effective options for anti-aging support.
Quality Standards
MASI produces its supplements in German facilities that adhere to rigorous quality protocols. They use high-grade raw materials sourced from select European suppliers [20]. This commitment to precision ensures each supplement meets stringent safety and performance benchmarks.
Every batch undergoes thorough testing to maintain these high standards:
| Test | Testing Location | Verification Method |
|---|---|---|
| Purity Analysis | Swiss Laboratory | Independent Testing |
| Microbiological Safety | Swiss Laboratory | Third-party Verification |
| Heavy Metal Content | Swiss Laboratory | Advanced Screening |
| Quality Certification | Germany | Manufacturing Standards |
Anti-Aging Product Line
MASI's dedication to quality is reflected in its product offerings, which include NMN, Resveratrol, Spermidine, and Fisetin. These formulations are designed to support energy production, cardiovascular and brain health, and cellular renewal:
NMN (Nicotinamide Mononucleotide)
- Delivers 1,000 mg of pure NMN per capsule
- Boosts NAD⁺ levels for enhanced energy metabolism
- Supports DNA repair and overall cellular health
Premium Resveratrol
- Contains 500 mg per capsule with 99% purity [21]
- Promotes heart health and improved circulation
- Enhanced bioavailability for better absorption
Spermidine
- Provides a 3 mg concentrated dose per capsule
- Encourages cellular renewal and maintenance
- Supports autophagy for healthy aging
Fisetin
- Offers 500 mg per capsule
- Reduces inflammation and oxidative stress
- Supports cognitive health and brain function
MASI Quality Difference
MASI’s products are developed with insights from a medical board that includes experts from Mayo Clinic and Harvard Medical School [20]. Their focus on excellence is evident in their formulations, which are:
- Vegan-friendly
- Free from GMOs, soy, lactose, and gluten
- Certified Halal and Kosher [20]
"I'm convinced that MASI supplements enhance cellular health and address several aging-related issues. It's a key component of my overall longevity strategy. This strategy includes MASI, regular exercise and a balanced diet, all working together to support a vibrant and healthy life in the years to come."
– Dr. Wolfgang Bucke, Ph.D., Senior Pharmacist and Board Member [21]
Clinical findings highlight the benefits of MASI’s NMN supplements. Users have reported reduced fatigue within weeks, leading to more active lifestyles [19]. Additionally, individuals aged 45 and older have noticed improved skin appearance with consistent use of NMN [19].
Summary
Sirtuin activation supplements are making waves in the field of longevity science. These enzymes play a key role in cellular repair, metabolism, and maintaining overall vitality. Understanding their function underscores the importance of using high-quality supplements to support them effectively.
As we age, sirtuin activity is impacted by declining NAD⁺ levels, especially after age 40. Supplements like NMN can help restore these levels, ensuring sirtuins remain active and functioning properly [23].
Experts emphasize the importance of sirtuins in aging:
"Sirtuins are indispensable for DNA repair, controlling inflammation and antioxidative defense which makes them good anti-senescence/anti-ageing targets" [3]
Building on this research, MASI has developed advanced formulations to maximize these benefits. Their supplements are designed with scientifically supported dosages:
| Supplement | Daily Dose | Primary Benefits |
|---|---|---|
| NMN | 1,000 mg | Supports NAD⁺ production and energy metabolism |
| Resveratrol | 500 mg | Promotes heart health and aids sirtuin activation |
| Spermidine | 3 mg | Encourages cellular renewal and autophagy |
| Fisetin | 500 mg | Enhances cognitive function and reduces inflammation |
These compounds work together to amplify their individual benefits, creating a synergistic effect that aligns with the natural processes of sirtuin activation. For the best results, supplements should be paired with a healthy lifestyle and taken consistently at the recommended dosages [22].
"By understanding the role of NMN in boosting NAD⁺ levels and supporting sirtuin function, we can better appreciate its potential in anti-aging strategies" [22] - MASI ANTI-AGING SCIENCE
MASI places a strong emphasis on quality and precision. Their products are engineered in Germany and undergo rigorous testing in Swiss laboratories to ensure purity and effectiveness. This dedication to excellence, combined with their thoughtfully crafted formulations, provides a solid path toward achieving longevity goals.
FAQs
How do NMN and Resveratrol work together to support healthy aging?
NMN (Nicotinamide Mononucleotide) and Resveratrol work hand-in-hand to support healthy aging by focusing on essential cellular functions. NMN plays a key role in increasing NAD+ levels - a molecule critical for energy production and DNA repair that naturally diminishes as we grow older. Meanwhile, Resveratrol activates sirtuins, particularly SIRT1, which are proteins responsible for regulating metabolism, managing stress responses, and controlling inflammation.
When combined, these two supplements promote better mitochondrial performance, enhance the body's ability to repair cells, and contribute to overall metabolic well-being. Their combined effects not only strengthen their individual roles but may also help sustain energy and support long-term vitality.
What lifestyle habits can boost the effectiveness of sirtuin activation supplements?
To get the most out of sirtuin activation supplements, pairing them with specific lifestyle habits can make a big difference. A diet rich in plants, consistent exercise, and practices like caloric restriction or intermittent fasting are especially effective. These habits naturally boost sirtuin activity, which helps improve metabolism, lower inflammation, and support cellular repair.
Take exercise, for instance - it not only raises NAD+ levels (a crucial component for activating sirtuins) but also directly triggers sirtuin activity, leading to better metabolic health and potentially longer life. Similarly, research indicates that caloric restriction may extend lifespan and enhance the benefits of supplements like NMN and resveratrol. By combining these lifestyle choices with supplements, you can create a powerful approach to support your health and energy.
What should I know about potential side effects or precautions when using sirtuin activation supplements like NMN and Fisetin?
Sirtuin activation supplements like NMN and Fisetin are generally considered safe for most people, but there are a few things to be aware of. For instance, some individuals taking NMN might experience mild side effects such as fatigue, headaches, dizziness, or stomach discomfort - especially when higher doses are involved. Similarly, while Fisetin is regarded as safe, it can sometimes lead to nausea, diarrhea, or an upset stomach, particularly if taken in large quantities.
Another point to consider is that Fisetin could potentially interact with certain medications by influencing how they’re metabolized in the liver. If you have any existing health conditions or are on medication, it’s wise to check with a healthcare professional before adding these supplements to your routine. This way, you can ensure they’re a good fit for your specific circumstances.
