Fights formation of cancer cells and activates the body’s defense against Alzheimer’s disease. Fisetin targets and eliminates senescent ‘zombie’ cells, which are a key factor in the aging process and the formation of age-related diseases like cancer, Alzheimer’s, and Parkinson’s. It also fights the core cause of allergies with powerful anti-inflammatory effects.
A key factor in aging is the increase in senescent or “zombie” cells as we age. The buildup of these cells is linked to the onset of age-related diseases such as diabetes, cancer, and dementia. Fisetin possesses the unique ability to aid the body in eliminating these harmful senescent cells. Regular consumption of MASI Premium Fisetin can help combat the accumulation of these cells, thereby bolstering your body’s defenses against age-related conditions like dementia, Parkinson’s, and Alzheimer’s.
Fisetin has been also found to promote apoptosis (or programmed cell death) in cancer cells and suppress their growth. These findings suggest fisetin can initiate cell death in many cancer cells while not harming normal cells.
Fisetin reduces the formation of new blood vessels, slows and can prevent the spread of cancer cells. It can inhibit an enzyme known as matrix metalloproteinase-1 used by cancer cells to spread within the body. Together, these properties help to prevent cancer cells from metastasizing and affecting nearby tissues.
Fisetin has been shown to improve long-term memory, to promote the growth of neurons, decrease oxidative stress on brain tissue, and reduce inflammation in brain cells beneficial in preventing Alzheimer's disease.
Fisetin is a powerful anti-inflammatory supplement that fights the core cause of allergies. According to Harvard’s Professor Alessio Fasano, multiyear research indicates that allergic reactions are not isolated events but symptoms of a broader, systemic inflammatory process within the body. By addressing inflammation at its source, Fisetin helps reduce allergic responses while also supporting overall health.
✓ Fight formation of cancer cells
✓ Eliminates "zombie" cells that contribute to aging
Fisetin, a natural flavonoid falling within the flavonol subclass of flavonoids, is a plant pigment abundant in various fruits and vegetables. It shares structural similarities with other flavonols like quercetin and kaempferol. Fisetin can be found in a range of plant-based foods, including strawberries, apples, persimmons, onions, and cucumbers. Its renowned antioxidant properties make it a valuable ally in neutralizing detrimental free radicals within the body, which can otherwise harm cells and contribute to diseases.
Beyond its antioxidant prowess, fisetin has garnered attention for its potential to support healthy aging, bolster brain health, enhance cardiovascular well-being, and more. Fisetin is readily available as an anti-aging supplement typically offered in the form of a concentrated extract of this natural compound. These longevity supplements are meticulously crafted to deliver a convenient and consistent source of fisetin, enabling individuals to tap into the remarkable health benefits associated with this flavonoid and potentially reverse aging effects.
Dosing
One capsule contains 250 mg of fisetin. A two-capsule serving provides 500 mg.
Recommended dosage:
40-50 years - 1 capsule per day;
50 years and more - 2 capsules per day
Serving & supply
Each jar contains 60 capsules. One capsule contains 250 mg fisetin. Two capsules provide 500 mg and a 30-day supply. One capsule daily gives up to 60 days of supply.
Fisetin Benefits
Fisetin has gained a lot of attention for its function as a senolytic compound. Senolytics are drugs or compounds that selectively target and eliminate senescent ‘zombie’ cells, which are cells that have stopped dividing and are no longer functioning properly. These cells can accumulate in the body with age and contribute to inflammation and age-related diseases.
Studies have shown that fisetin may help selectively eliminate senescent cells in mice and improve markers of health and longevity. For example, a study published in the journal eBioMedicine found that fisetin supplementation in mice improved physical function, reduced markers of inflammation, and increased lifespan1. Of the 10 flavonoids tested, fisetin was the most potent senolytic.
In addition, there are several other pathways in which Fisetin may help support healthy aging:
Chronic inflammation has been linked to a variety of age-related diseases, and fisetin has been shown to help reduce inflammation in the body2–4.
Fisetin is a powerful antioxidant, which means it helps to neutralise harmful free radicals in the body that can damage cells and contribute to aging. Fisetin functions, at least in part, via interactions with redox signalling pathways, and modulation of the NF-κB, Nrf2, MAPK and PI3K/Akt signalling pathways5,6.
Fisetin has been shown to help support healthy cellular function and to protect DNA from damage7,8, which can contribute to cellular aging and disease.
While the exact mechanisms by which fisetin may increase longevity are still being studied, it is clear that this natural flavonoid has a variety of health benefits that support healthy aging.
Improving health and longevity depends on individual factors such as age, diet, and lifestyle. To maximise the benefits of our supplements, we recommend incorporating them into a comprehensive anti-aging regimen that includes healthy eating, regular exercise, and other lifestyle factors that promote longevity and healthy aging.
Absorbs effectively with advanced formulationsStudy
References
1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. eBioMedicine. 2018;36:18-28. doi:10.1016/j.ebiom.2018.09.015
2. Huang W, Li ML, Xia MY, Shao JY. Fisetin-treatment alleviates airway inflammation through inhibition of MyD88/NF-κB signaling pathway. Int J Mol Med. 2018;42(1):208-218. doi:10.3892/ijmm.2018.3582
3. Molagoda IMN, Jayasingha JACC, Choi YH, Jayasooriya RGPT, Kang CH, Kim GY. Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock. Sci Rep. 2021;11(1):8377. doi:10.1038/s41598-021-87257-0
4. Sun Y, Qin H, Zhang H, et al. Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells. Food Nutr Res. 2021;65. doi:10.29219/fnr.v65.6355
5. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: A Dietary Antioxidant for Health Promotion. Antioxid Redox Signal. 2013;19(2):151-162. doi:10.1089/ars.2012.4901
6. Naeimi AF, Alizadeh M. Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies. Trends Food Sci Technol. 2017;70:34-44. doi:10.1016/j.tifs.2017.10.003
7. Wang T, Lin H, Tu Q, Liu J, Li X. Fisetin Protects DNA Against Oxidative Damage and Its Possible Mechanism. Adv Pharm Bull. 2016;6(2):267. doi:10.15171/apb.2016.037
8. Park C, Noh JS, Jung Y, et al. Fisetin Attenuated Oxidative Stress-Induced Cellular Damage in ARPE-19 Human Retinal Pigment Epithelial Cells Through Nrf2-Mediated Activation of Heme Oxygenase-1. Front Pharmacol. 2022;13. Accessed March 12, 2023. https://www.frontiersin.org/articles/10.3389/fphar.2022.927898
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★★★★★
Premium Fisetin
I have much more energy and my appetite is under control.
Deborah
★★★★★
Just started on supplements, I add this with multi-vitamins and taurine
After hearing so much about Fisetin, I decided to give it a shot. It's been a game-changer for my energy levels and overall sense of wellness. Highly recommend it to my peers.
Lana
★★★★★
So, I gave those longevity pills a shot
So, I gave those longevity pills a shot, and honestly, I'm impressed. I didn't expect much at first, but over the past few weeks, I've noticed a marked improvement in my energy levels and overall mood.…
Beckett
★★★★★
Gave Fisetin a try and it's quietly revolutionizing my approach to aging and wellness
I've been using Fisetin for a couple of months now, and the difference in my cognitive function and physical stamina is noticeable. It's become a staple in my quest for healthy aging
Giselle
Enhanced Cellular Renewal with Spermidine Tied to Age-Well Benefits
What is Fisetin?
Fisetin, a flavonoid naturally present in fruits like strawberries. Its origin from plants has led to research on its anti-aging applications. One of its key functions is the reduction of senescent cells, which are linked to aging and degenerative diseases. Studies indicate fisetin can extend lifespan in certain models by up to 10%, emphasizing its role in aging.
Additionally, it acts as a potent antioxidant, addressing oxidative stress, a major factor in the aging process. It also supports brain health, potentially reducing the incidence of neurodegenerative conditions. David Sinclair, a renowned longevity scientist, incorporates 500mg of fisetin into his supplement regimen, highlighting its importance in promoting healthy aging. Fisetin's multifaceted approach to aging, from senescent cells also known as "zombie cells" that no longer divide but accumulate as we age, causing various health issues. It's like a cleanup crew, removing these cells to promote healthier aging.
Fisetin
Your daily routine
Eliminate senescent aging cells & increase brain health in as little as 45 days.
“I'm convinced that MASI supplements enhance cellular health and address several aging-related issues. It's a key component of my overall longevity strategy. This strategy includes MASI, regular exercise and a balanced diet, all working together to support a vibrant and healthy life in the years to come.”
Dr.Wolfgang Bucke, Ph.D.,Senior Pharmacist and Board Member
Pure transparency
From source to capsule.
See each step, from ingredients to delivery.
About our process
MASI is the only line of longevity supplements featuring 100% German materials & engineering.
MASI prioritizes honesty and transparency. While most companies vaguely claim "made in [country]" without proof, we openly share our entire process. Ensuring our customers have the full, verifiable story.
01Sourced in Germany
MASI proudly upholds an unwavering standard by utilizing 100% German raw materials, ensuring zero components are sourced from China. This commitment harnesses the renowned high-quality German engineering, merging meticulous craftsmanship with stringent quality controls. Our dedication to sourcing exclusively within Germany guarantees that each product not only meets but exceeds expectations, offering a synergy of superior engineering and absolute purity, unmatched in the realm of NMN brands.
02Produced in Germany
MASI's commitment to superior longevity supplements is rooted in our pharmaceutical-grade German facilities. Each product stands as a testament to unmatched quality and purity, crafted through an advanced enzymatic process, not chemicals, ensuring a pristine formula. Ingredients and dietary suitability vary by product. Check each product page for ingredient and allergen information.
03Encapsulated in Germany
Meticulously crafted, our capsules represent the pinnacle of purity and environmental responsibility, sourced from sustainable German pine tree extract. Advanced precision technology ensures consistent dosages for reliable efficacy, while the thoughtfully engineered composition maximizes bioavailability and digestibility, offering a gentle touch on your digestive system. These 100% vegan capsules reflect our commitment to delivering safe, effective health solutions, encapsulating the essence of Germany's botanical treasures in a pristine, contaminant-free process, for a superior, stomach-friendly wellness experience
04Tested in Switzerland
Our products are rigorously third-party tested in Swiss laboratories, including independent verification by an accredited facility, ensuring unmatched standards of purity and safety. Each batch is meticulously analyzed for purity, microbiology—to detect and eliminate harmful microorganisms—and heavy metals like lead, mercury, and cadmium. This comprehensive testing assures the hygiene, purity, and utmost safety of our supplements, reflecting our commitment to delivering contaminant-free, trusted wellness solutions in every pristine batch
05Bottled in Germany
Ensuring precision in every capsule, our supplements are bottled in a pharmaceutical-grade facility in Germany, renowned for its meticulous standards. This process guarantees exact product amounts in each capsule, upheld by rigorous quality controls for unmatched consistency. This commitment to precision, coupled with our adherence to the highest standards of safety and purity, ensures that every dose delivers the trusted, effective wellness solutions our customers expect
06Shipped from Europe
Leveraging multiple European facilities, our shipping process ensures exceptionally fast product arrival at minimal costs. With our expansion, new satellite facilities in Australia and the United States further enhance our efficiency, promising speedier delivery, economical rates, and straightforward returns. This robust network guarantees not just swift, but also cost-effective and convenient service, making each order a testament to our commitment to unparalleled customer satisfaction
Lab Results
Independent Fisetin lab reports.
Read the independent Swiss laboratory reports below. Each report applies to its stated product and batch.
Age 30-45, notices the body's evolving needs, observing the emergence of wrinkles and fine lines, sensing emotional reactions to aging and experiencing a decline in energy and memory.
Science-based thinkiners, motivated by scientific research and discoveries, fascinated by the pursuit of graceful aging and longevity, dedicated to investing time and resources in anti-aging strategies.
Advocates for healthy lifestyle choices, strongly focused on a nutritious diet and regular exercise, committed to proactive change and the use of supplements for well-being.
Age 45-80, visible signs of aging, decline in skin elasticity and firmness, increases physical fatigue, memory lapses, mild to extreme cognitive decline, pursuing enhancements in the essential years, aspiring for overall well-being.
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Frequently Asked Questions
What is Fisetin?
Fisetin is a flavonoid compound with antioxidant properties, found in various fruits and vegetables.
How does Fisetin work in the body?
Fisetin works by reducing oxidative stress and inflammation, potentially slowing down the aging process at the cellular level.
Can Fisetin help with anti-aging?
Yes, Fisetin has shown positive data for having anti-aging effects by promoting cellular health and longevity.
What are the main health benefits of Fisetin?
The main benefits include antioxidant effects, potential improvement in brain health, and support in cellular function and longevity.
How much Fisetin should I take daily?
The optimal daily dosage of Fisetin 250mg for ages 50 and under and 500mg for ages 50 and over.
Are there any side effects of taking Fisetin?
Fisetin is considered safe, but high doses might cause side effects; it's best to consult with a healthcare provider.
Can Fisetin interact with other medications?
Fisetin may interact with certain medications; it's important to always do research and consult a healthcare provider when mixing medications.
What foods are rich in Fisetin?
Foods rich in Fisetin include strawberries, apples, persimmons, and onions.
How long does it take to see the effects of Fisetin?
The time to notice effects can vary; consistent, long-term use is generally needed to observe benefits. Studies have shown results in as little as 2 weeks.
Is Fisetin safe for everyone to use?
Fisetin is safe for most people, but pregnant or nursing individuals and those with health conditions should consult a doctor first.
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