Fisetin, a natural compound found in strawberries and apples, helps remove aging cells (senescent cells) that contribute to inflammation and age-related diseases. It works by targeting harmful pathways in these "zombie cells" and reducing their negative effects on the body. Research shows that Fisetin can improve physical endurance, lower inflammation markers, and support healthier aging.
Key Takeaways:
- What it does: Clears out aging cells to promote cellular renewal.
- How it works: Disrupts pathways these cells rely on and reduces harmful secretions (SASP factors).
- Benefits: May lower risks of diseases like dementia, diabetes, and cancer.
- Dosage: 500 mg/day for ages 40–50, 1,000 mg/day for 50+.
- Research-backed: Studies show reduced inflammation and improved physical performance.
MASI Longevity Science offers a Fisetin supplement made in Germany, tested for purity, and tailored for cellular health. It's vegan, allergen-free, and independently verified for safety and effectiveness.
How Fisetin Works as a Senolytic
Removing Senescent Cells
Fisetin helps clear out senescent cells by disrupting the PI3K/AKT/mTOR pathway, which these cells depend on to avoid programmed cell death. Research on human fibroblast cultures reveals that Fisetin can reduce the viability of these cells by 50–70% [1].
It also reduces the harmful effects of senescence by lowering the secretion of SASP (senescence-associated secretory phenotype) factors. For example, animal studies found that an oral dose of 100 mg/kg Fisetin lowered IL-6 levels by 65%. Similarly, in irradiated human lung cells, SASP-related gene expression dropped by 40–80% [2][4].
Research Findings So Far
Preclinical studies have shown that Fisetin improves physical endurance and decreases the number of senescent cells in older animals. In a 2023 Phase 2 trial, older adults taking 20 mg/kg/day for two consecutive days each month saw an 18% reduction in p16INK4A levels, a 12% improvement in their 6-minute walk distance, and a 22% drop in CRP markers [3].
In another study focusing on endothelial cells, a 20 μM concentration of Fisetin removed up to 90% of senescent cells while leaving healthy cells unharmed [3]. These findings highlight Fisetin's potential to target aging at the cellular level, making it a promising option in anti-aging therapies.
Using Fisetin Effectively
Recommended Dosage
MASI Longevity Science provides age-based dosage recommendations for Fisetin, reflecting its role in supporting cellular health. Here's the suggested daily intake:
| Age Group | Daily Dosage | Pure Fisetin Amount |
|---|---|---|
| 40–50 years | 1 capsule | 500 mg |
| 50+ years | 2 capsules | 1,000 mg |
Each capsule contains 500 mg of pure Fisetin, ensuring consistent strength. Stick to these guidelines for the best results.
Supplement Guidelines
To get the most out of Fisetin, consider these key points:
Quality Standards:
MASI's Fisetin undergoes independent testing in Switzerland to confirm its purity and potency. It's also non-GMO, allergen-free, vegan, Halal, and Kosher.
Who Can Benefit:
This supplement is ideal for individuals over 40 who are focused on long-term wellness. It may help if you're looking to:
- Maintain energy levels as you age
- Support overall health for the years ahead
- Promote better cellular health
Safety Measures:
MASI works with experts from Harvard Medical School and Mayo Clinic to ensure their Fisetin supplements meet strict safety standards. They are designed for optimal absorption and effectiveness, supporting your health goals with confidence.
FISETIN: How it AFFECTS Senescent Cells
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Fisetin's Key Benefits
Fisetin offers clear advantages for maintaining and supporting cellular health through its unique molecular actions.
Senolytic Properties
Fisetin acts as a senolytic, targeting and removing senescent cells - those older, dysfunctional cells that can contribute to aging and disease. MASI Longevity Science's Fisetin formulation is based on research from Harvard Medical School and Mayo Clinic, focusing on this critical aspect of cellular aging.
Health and Aging Effects
Fisetin provides several key benefits, including:
- Cellular Renewal: Helps refresh the body by clearing out aged, damaged cells.
- Support Against Age-Related Conditions: By addressing cellular aging, Fisetin may reduce the likelihood of issues like dementia, cancer, Alzheimer's, Parkinson's, and diabetes.
MASI's Fisetin formula is produced in Germany and undergoes independent testing in Swiss laboratories to ensure its potency and purity. This approach reflects a focused effort to address age-related cellular decline, contributing to advancements in longevity science.
MASI Longevity Science Fisetin
MASI's Fisetin supplement is crafted with pharmaceutical-grade standards and precise dosing to support health and longevity.
MASI's Quality Standards
MASI Longevity Science ensures top-tier quality control throughout its production process. The Fisetin supplement is manufactured in a state-of-the-art German facility using certified German raw materials.
"At MASI, we pride ourselves on offering the purest and highest quality products to support your health and longevity journey. Our supplements are manufactured to a standard not yet seen in the industry, setting a new benchmark for product quality. The MASI benchmark." - MASI Longevity Science [1]
Each batch undergoes independent testing at accredited Swiss laboratories. Key tests include:
| Test Parameter | Verification Process |
|---|---|
| Purity Analysis | Comprehensive molecular testing |
| Microbiological Safety | Full spectrum contamination screening |
| Heavy Metal Content | Advanced metals detection analysis |
| Quality Verification | Independent third-party certification |
Customers can access detailed test results through a QR code included with the product or on MASI's website. This ensures full transparency and trust in their process.
Supporting Cellular Health
MASI's stringent production standards ensure that every dose delivers optimal support for cellular renewal. Each capsule contains 500mg of Fisetin, specifically formulated for cellular health and tailored to age-specific dosing recommendations.
"MASI is the only manufacturer to our knowledge crafting NMN, Spermidine, Fisetin and Resveratrol supplements in Germany using premium, German-sourced raw materials." - MASI Longevity Science [1]
The supplement is vegan, non-GMO, and free from soy, lactose, gluten, and common allergens. It is also certified Halal and Kosher. Designed with advanced scientific research, MASI's Fisetin ensures both safety and effectiveness, with absorption and bioavailability optimized for maximum impact on cellular health.
Summary
Fisetin is a natural compound that helps remove aging cells, supporting cellular health and balance. Research highlights its role in aiding the body's natural renewal processes and promoting overall well-being as we age.
The suggested daily dose is 500 mg for individuals aged 40–50 and 1,000 mg for those over 50. MASI's Fisetin is made in Germany, using high-quality raw materials and undergoing independent testing to ensure purity and effectiveness.
FAQs
What is Fisetin, and how does it help remove aging cells from the body?
Fisetin is a naturally occurring compound found in fruits and vegetables like strawberries, apples, and onions. It acts as a senolytic agent, meaning it selectively targets and eliminates senescent cells - damaged or aging cells that no longer function properly but still linger in the body. By clearing these cells, Fisetin helps reduce inflammation, supports cellular renewal, and promotes overall healthy aging.
Research suggests that Fisetin works by influencing specific pathways in senescent cells, triggering their removal while leaving healthy cells unaffected. This process may contribute to improved vitality, better heart and brain health, and enhanced longevity when combined with a balanced lifestyle and proper supplementation.
What are the long-term health benefits of using Fisetin to support healthy aging?
Fisetin is a powerful senolytic compound that works by targeting and clearing senescent cells - damaged cells that accumulate as we age and contribute to various age-related conditions. By reducing the burden of these cells, Fisetin may help promote healthier aging and support overall vitality.
Potential long-term benefits of taking Fisetin include improved cellular renewal, enhanced heart and brain health, and a lower risk of age-related diseases. Incorporating Fisetin into your routine may also contribute to a longer, healthier life by addressing one of the key underlying causes of aging.
Are there any potential side effects or risks of taking Fisetin, and do they vary by age?
Fisetin is generally considered safe when taken at recommended dosages, but research on its side effects or risks across different age groups is still limited. Most studies suggest that it is well-tolerated, with no significant adverse effects reported in healthy individuals. However, as with any supplement, individual responses may vary.
Before starting Fisetin or any new supplement, it’s a good idea to consult with a healthcare professional, especially if you have pre-existing health conditions, are pregnant, nursing, or are taking medications. Staying informed and using products from trusted sources ensures the best support for your health and longevity goals.
