Aging is very much related to reduced autophagy and weight gain. Spermidine helps maintain a healthy weight and slows down aging by enhancing cellular renewal. It also fights dementia development and protects long-term brain health. Backed by human clinical studies, MASI Premium Spermidine targets key factors of aging:
Spermidine has been scientifically shown to effectively promote weight loss, particularly in obese individuals. It improves metabolic function, leading to reduced body fat and aiding in weight management. Maintaining a healthy weight is essential for optimal health and slowing down the aging process.
In addition to its weight loss benefits, Spermidine plays a crucial role in enhancing autophagy, the body’s natural process of removing damaged cells. A study published by the National Library of Medicine on November 9, 2020, concluded that Spermidine supplementation not only leads to significant weight loss but also improves insulin resistance by boosting autophagy. This process improves gut microbiota composition and function, providing protection against obesity. The researchers concluded that “Spermidine supplementation may serve as a viable therapy for obesity.” Additionally, Spermidine helps improve gut barrier integrity and overall gut health, further contributing to its anti-aging effects.
Scientific studies have showed significant improvements in short and medium-term memory and also cessation of senile dementia when spermidine was given. The other study has confirmed that dietary spermidine intake might improve memory performance in older individuals
✓ Facilitates weight loss
✓ Promotes a healthy autophagy process
✓ Optimizes mitochondrial energy production
✓ Fights dementia development
Spermidine, a natural polyamine, is a ubiquitous presence in all living cells, spanning humans, animals, plants, and bacteria. It can be synthesized by the body or acquired through dietary sources and plays a crucial role in numerous cellular functions, encompassing cell growth, differentiation, and programmed cell death. Additionally, spermidine is vital for preserving the integrity and functionality of DNA, RNA, and proteins. Its significance extends to various physiological processes, including immune system support, cardiovascular well-being, and cognitive function, promoting vitality.
Notably, spermidine has garnered recognition as an anti-aging supplement due to its capacity to stimulate autophagy—a cellular process that aids in the breakdown and recycling of damaged cellular components, ultimately enhancing cellular health and contributing to longevity. Although spermidine can be found in various foods such as mushrooms, soybeans, legumes, and whole grains, its concentrations are relatively low. Hence, for those seeking to harness its anti-aging and longevity-promoting benefits, dietary supplementation is often the most effective approach.
Dosing
One capsule contains 1.5 mg of spermidine. A two-capsule serving provides 3 mg.
Recommended dosage:
40-50 years - 1 capsule per day;
50 years and more - 2 capsules per day
Serving & supply
Each jar contains 60 capsules. One capsule contains 1.5 mg spermidine. Two capsules provide 3 mg and a 30-day supply. One capsule daily gives up to 60 days of supply.
Spermidine Benefits
Spermidine has been shown to increase longevity in various model organisms, including yeast, worms, flies, mice, and human cells1. The mechanisms by which spermidine exerts its anti-aging effects is primarily through autophagy, a process by which cells degrade and recycle damaged components, leading to better cellular health and longevity.
Autophagy is a natural cellular process that helps maintain cellular homeostasis by degrading and recycling damaged proteins and organelles. As we age, the efficiency of autophagy decreases, leading to a buildup of damaged cellular components and an increased risk of age-related diseases6. Spermidine has been found to induce autophagy by altering the acetylation status of the chromatin, resulting in reduced oxidative stress and an extended life span of yeast, flies and worms, and human immune cells5.
A human epidemiological study that investigated the association between dietary intake of spermidine and all cause mortality, found that nutrition rich in spermidine is linked to increased survival in humans7.
In addition to promoting autophagy, spermidine has also been found to have other beneficial effects on cellular and organismal health, such as reducing oxidative stress and inflammation1,5, and improving mitochondrial function8,9. These mechanisms likely contribute to the anti-aging effects of spermidine.
Spermidine has been shown to improve cardiovascular health. In animal studies, supplementation of spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy, preserving diastolic function, enhanced cardiac autophagy and mitochondrial respiration, and improved the mechano-elastical properties of the contractile cardiac cells (cardiomyocytes)4. Spermidine was also found to alleviate cardiac aging by improving mitochondrial biogenesis and function9. In humans, high levels of dietary spermidine correlated with reduced blood pressure and a lower incidence of cardiovascular disease4.
Spermidine also supports healthy brain function. The latest research has demonstated the beneficial effects of dietary spermidine intake on cognitive performance in flies, mice, and
humans3. High dietary spermidine intake improved cognitive function in animal models, and in epidemiological studies correlated with a reduced risk of cognitive impairment in humans. The cognitive improvements were in part due to increased mitochondrial respiration in neuronal animal tissues, which was dependent on autophagy.
Improving health and longevity depends on individual factors such as age, diet, and lifestyle. To maximise the benefits of our supplements, we recommend incorporating them into a comprehensive anti-aging regimen that includes healthy eating, regular exercise, and other lifestyle factors that promote longevity and healthy aging.
1. Minois N. Molecular Basis of the ‘Anti-Aging’ Effect of Spermidine and Other Natural Polyamines - A Mini-Review. Gerontology. 2014;60(4):319-326. doi:10.1159/000356748
2. Pegg AE. Functions of Polyamines in Mammals. J Biol Chem. 2016;291(29):14904-14912. doi:10.1074/jbc.R116.731661
3. Schroeder S, Hofer SJ, Zimmermann A, et al. Dietary spermidine improves cognitive function. Cell Rep. 2021;35(2):108985. doi:10.1016/j.celrep.2021.108985
4. Eisenberg T, Abdellatif M, Schroeder S, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22(12):1428-1438. doi:10.1038/nm.4222
5. Eisenberg T, Knauer H, Schauer A, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009;11(11):1305-1314. doi:10.1038/ncb1975
6. Barbosa MC, Grosso RA, Fader CM. Hallmarks of Aging: An Autophagic Perspective. Front Endocrinol. 2019;9. Accessed March 12, 2023. https://www.frontiersin.org/articles/10.3389/fendo.2018.00790
7. Kiechl S, Pechlaner R, Willeit P, et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018;108(2):371-380. doi:10.1093/ajcn/nqy102
8. Hofer SJ, Liang Y, Zimmermann A, et al. Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging. Autophagy. 2021;17(8):2037-2039. doi:10.1080/15548627.2021.1933299
9. Wang J, Li S, Wang J, et al. Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function. Aging. 2020;12(1):650-671. doi:10.18632/aging.102647
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★★★★★
Back to my pre-pandemic weight
I gained a lot of weight during the pandemic which has been lingering with me for a while now. After adding spermidine to my daily routine i’ve noticed gradual improvements in weight loss and overall health!!
Nadine
★★★★★
Weight loss after 45
Losing weight has become a challenge after I hit 45. I decided to start taking Spermidine a few months ago and steadily the results have become noticeable, i’m finally seeing progress again.
Tobias M
★★★★★
Simple yet effective
I don’t like taking too many supplements but spermidine has worked great for me. I feel improvements in strength and overall health. I’ve also lost some weight which I believe Spermidine had some impact on as well..
Camila Y
★★★★★
As a healthy, menopausal 58 year old female who has been active and a runner most of my life, (& a big supplement fan), I had a few chronic injuries off and on, (plantar fasciitis & hamstring tear at the glute) and the usual aches and pains of getting older
As a healthy, menopausal 58 year old female who has been active and a runner most of my life, (& a big supplement fan), I had a few chronic injuries off and on, (plantar fasciitis & hamstring tear at the glute) and the usual aches and pains of getting older.…
rebecca B.
Enhanced Cellular Renewal with Spermidine Tied to Age-Well Benefits
What is Spermidine?
Spermidine, a polyamine discovered in 1678, is found in foods like aged cheese, mushrooms, and legumes. It's known for promoting autophagy, aiding in cellular renewal, which is vital for anti-aging. Spermidine may improve cardiovascular health, reduce blood pressure, and offer neuroprotective benefits and lowering the risk of neurodegenerative diseases.
David Sinclair, a renowned longevity scientist, incorporates 1mg of Spermidine daily into his anti-aging regimen. This practice is rooted in Spermidine's role in promoting autophagy, the body's process of cellular cleanup and renewal, which is crucial for maintaining cellular health and longevity. His approach reflects a growing interest in leveraging natural compounds to support the body's own
Spermidine
Your daily routine
Increase autophagic activity by up to 30% enhancing cellular rejuvenation.
“I'm convinced that MASI supplements enhance cellular health and address several aging-related issues. It's a key component of my overall longevity strategy. This strategy includes MASI, regular exercise and a balanced diet, all working together to support a vibrant and healthy life in the years to come.”
Dr.Wolfgang Bucke, Ph.D.,Senior Pharmacist and Board Member
Pure transparency
From source to capsule.
See each step, from ingredients to delivery.
About our process
MASI is the only line of longevity supplements featuring 100% German materials & engineering.
MASI prioritizes honesty and transparency. While most companies vaguely claim "made in [country]" without proof, we openly share our entire process. Ensuring our customers have the full, verifiable story.
01Sourced in Germany
MASI proudly upholds an unwavering standard by utilizing 100% German raw materials, ensuring zero components are sourced from China. This commitment harnesses the renowned high-quality German engineering, merging meticulous craftsmanship with stringent quality controls. Our dedication to sourcing exclusively within Germany guarantees that each product not only meets but exceeds expectations, offering a synergy of superior engineering and absolute purity, unmatched in the realm of NMN brands.
02Produced in Germany
MASI's commitment to superior longevity supplements is rooted in our pharmaceutical-grade German facilities. Each product stands as a testament to unmatched quality and purity, crafted through an advanced enzymatic process, not chemicals, ensuring a pristine formula. Ingredients and dietary suitability vary by product. Check each product page for ingredient and allergen information.
03Encapsulated in Germany
Meticulously crafted, our capsules represent the pinnacle of purity and environmental responsibility, sourced from sustainable German pine tree extract. Advanced precision technology ensures consistent dosages for reliable efficacy, while the thoughtfully engineered composition maximizes bioavailability and digestibility, offering a gentle touch on your digestive system. These 100% vegan capsules reflect our commitment to delivering safe, effective health solutions, encapsulating the essence of Germany's botanical treasures in a pristine, contaminant-free process, for a superior, stomach-friendly wellness experience
04Tested in Switzerland
Our products are rigorously third-party tested in Swiss laboratories, including independent verification by an accredited facility, ensuring unmatched standards of purity and safety. Each batch is meticulously analyzed for purity, microbiology—to detect and eliminate harmful microorganisms—and heavy metals like lead, mercury, and cadmium. This comprehensive testing assures the hygiene, purity, and utmost safety of our supplements, reflecting our commitment to delivering contaminant-free, trusted wellness solutions in every pristine batch
05Bottled in Germany
Ensuring precision in every capsule, our supplements are bottled in a pharmaceutical-grade facility in Germany, renowned for its meticulous standards. This process guarantees exact product amounts in each capsule, upheld by rigorous quality controls for unmatched consistency. This commitment to precision, coupled with our adherence to the highest standards of safety and purity, ensures that every dose delivers the trusted, effective wellness solutions our customers expect
06Shipped from Europe
Leveraging multiple European facilities, our shipping process ensures exceptionally fast product arrival at minimal costs. With our expansion, new satellite facilities in Australia and the United States further enhance our efficiency, promising speedier delivery, economical rates, and straightforward returns. This robust network guarantees not just swift, but also cost-effective and convenient service, making each order a testament to our commitment to unparalleled customer satisfaction
Lab Results
Independent Spermidine lab reports.
Read the independent Swiss laboratory reports below. Each report applies to its stated product and batch.
Age 30-45, notices the body's evolving needs, observing the emergence of wrinkles and fine lines, sensing emotional reactions to aging and experiencing a decline in energy and memory.
Science-based thinkiners, motivated by scientific research and discoveries, fascinated by the pursuit of graceful aging and longevity, dedicated to investing time and resources in anti-aging strategies.
Advocates for healthy lifestyle choices, strongly focused on a nutritious diet and regular exercise, committed to proactive change and the use of supplements for well-being.
Age 45-80, visible signs of aging, decline in skin elasticity and firmness, increases physical fatigue, memory lapses, mild to extreme cognitive decline, pursuing enhancements in the essential years, aspiring for overall well-being.
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Frequently Asked Questions
What is Spermidine?
Spermidine is a naturally occurring polyamine that plays a role in cellular growth, renewal, and overall health.
How does Spermidine support anti-aging?
Spermidine promotes autophagy, a process that removes cellular waste and may slow aging at the cellular level.
Can Spermidine reverse signs of aging?
While Spermidine can support cellular health, it cannot completely reverse signs of aging but may slow the aging process.
Is Spermidine safe to take?
Spermidine is generally safe but consult a healthcare provider for personalized guidance, especially at higher doses.
What is the recommended dosage for Spermidine supplements?
The recommended dosage varies; For individuals under the age of 50, 1.5mg is recommended, for individuals over 50, 3mg is recommended. Consult a healthcare provider to determine the right amount based on individual needs.
Are there any side effects of taking Spermidine?
Side effects are uncommon but can include gastrointestinal discomfort; consult a doctor if you have concerns.
Can Spermidine supplements be taken with other medications?
It's best to consult with a healthcare provider, as Spermidine may interact with certain medications.
How long does it take to see the effects of Spermidine supplements?
The effects can vary; consistent, long-term use is typically needed to notice benefits. However studies have shown results in as little as 2 weeks.
Can Spermidine aid in weight management?
Some studies suggest Spermidine may have positive effects on metabolic health, but it's not primarily used for weight management.
Who should avoid taking Spermidine supplements?
Pregnant or nursing individuals, those with specific health conditions, or those on certain medications should consult a doctor before use.
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