Bifidobacterium lactis is a probiotic that supports gut and immune health, especially for older adults. Aging weakens the immune system, but research shows that specific strains like HN019 and Bi-07 improve immune cell activity, reduce inflammation, and enhance gut barrier function. Key benefits include:
- Boosts immune cells: Natural Killer (NK) cell activity increases by up to 62%.
- Reduces inflammation: Pro-inflammatory markers like IL-6 decrease by up to 22%.
- Enhances gut health: Strengthens gut barriers and restores gut balance.
- Supports vaccine response: Combined strains improve vaccine efficacy by 48%.
Quick Comparison of B. lactis Strains
| Feature | HN019 | Bi-07 |
|---|---|---|
| Primary Benefit | NK cell activation (62%) | Neutrophil function (27%) |
| Anti-inflammatory Impact | IL-6 reduction (15%) | IL-6 reduction (22%) |
| Optimal Dose | 2.5–6 billion CFU | 1–5 billion CFU |
| Time to Peak Effect | 4 weeks | 8 weeks |
For best results, combine B. lactis with prebiotics and supplements like NMN or Resveratrol. Benefits appear within 6–8 weeks and are safe for most older adults when taken as directed. Always consult your doctor before starting new supplements.
Immune System Effects of Bifidobacterium lactis
Effects on Immune Cell Activity
Bifidobacterium lactis plays a key role in improving immune cell function, particularly in older adults. Research indicates that the strain B. lactis HN019 can boost mononuclear cell phagocytic activity by 54% and enhance polymorphonuclear cell function by 32% in elderly individuals. Additionally, supplementation increases CD4⁺ T helper cells and CD25⁺ activated T lymphocytes, which are essential for coordinating the immune system's response to harmful pathogens [4]. These cellular improvements contribute to a more resilient gut defense system.
Gut Barrier Protection
The strain B. lactis CNCM-I2494 strengthens the gut barrier by increasing claudin-4 expression by 2.3 times, restoring goblet cell populations to 89% of their normal levels, and reducing pro-inflammatory markers IL-8 and TNF-α by 67% and 41%, respectively [1][2]. A healthier gut barrier supports the immune system by enhancing the function and activation of natural killer cells.
Natural Killer Cell Function
B. lactis HN019 significantly enhances natural killer (NK) cell performance:
| NK Cell Parameter | Improvement |
|---|---|
| Cell Count | 21% increase |
| Tumoricidal Activity | 48% enhancement |
| Viral Clearance | 1.8× improvement |
These benefits also include a 35% increase in granzyme B and a 28% rise in perforin levels, which are critical for NK cell activity. For optimal results, a daily dose of 5×10¹⁰ CFU is recommended. However, even lower doses can achieve up to 89% of the maximum effect. Taking the supplement in the morning with prebiotic fibers further enhances bacterial survival by 47% [3][4].
Research on Different B. lactis Strains
Studies on B. lactis HN019
Clinical trials have shown that B. lactis HN019 supports immune health in older adults. In a 2021 randomized controlled trial with 220 participants, a daily intake of 6 billion CFU led to a 62% increase in natural killer (NK) cell activity, a 19% boost in T-cell proliferation, and a 35% reduction in upper respiratory infections over a 12-week period in adults aged 65 and older [1].
Key improvements in immune markers included:
| Immune Parameter | Improvement |
|---|---|
| NK Cell Activity | 62% increase |
| T-Cell Proliferation | 19% increase |
| Secretory IgA Levels | 40% increase |
| Infection Reduction | 35% decrease |
Research on B. lactis Bi-07
B. lactis Bi-07 has been studied for its role in modulating immune function. A 2023 study in the Journal of Gerontology found that a daily dose of 5 billion CFU improved neutrophil phagocytosis capacity by 27% and reduced pro-inflammatory IL-6 levels by 22% in adults aged 70–85 [2]. The study also confirmed the strain's safety.
Additional findings include:
- A 2022 influenza vaccine trial showed that Bi-07 supplementation resulted in 28% faster seroconversion rates compared to placebo groups [7].
- Separate research reported a 42% improvement in monocyte phagocytosis over a 21-day period [8].
B. lactis Strain Comparison
Both HN019 and Bi-07 enhance immune function, but they do so through different mechanisms:
| Characteristic | HN019 | Bi-07 |
|---|---|---|
| Primary Immune Effect | NK cell activation (62%) | Neutrophil function (27%) |
| Anti-inflammatory Impact | 15% IL-6 reduction | 22% IL-6 reduction |
| Optimal Daily Dose | 2.5–6 billion CFU | 1–5 billion CFU |
| Peak Efficacy Timeline | 4 weeks | 8 weeks |
A 2024 pilot study revealed that combining HN019 and Bi-07 led to a 48% higher vaccine response rate compared to single-strain supplementation. The combination group also maintained protective antibody levels for 3 weeks longer post-vaccination [5].
Both strains are compatible with common medications used by seniors, such as statins and metformin. However, individuals on immunosuppressants should consult their healthcare provider [4]. Benefits typically appear within 4–12 weeks, and long-term use has been linked to a 40% reduction in winter hospitalization rates after six months [6].
These findings highlight how each strain offers distinct advantages, making them a strong option for personalized supplementation strategies in older adults.
Using B. lactis with MASI Products
Pairing with NMN and Resveratrol
Combine B. lactis with MASI NMN and Resveratrol for support in managing aging processes. For adults aged 40–50, take one capsule of each. Those aged 50 and above should take two capsules of each. MASI supplements are produced in Germany and undergo Swiss quality testing. This combination helps support cellular renewal.
Including Spermidine for Added Support
Incorporate MASI Spermidine into your routine to further promote cellular renewal and round out your anti-aging approach.
Building a Complete Routine
For a comprehensive anti-aging regimen, start with B. lactis and MASI NMN as your base. Then, include MASI Resveratrol and Spermidine to support antioxidant activity and cellular health. Always consult your healthcare provider before beginning any new supplements.
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Pharmacology of Bifidobacterium Lactis ; Mechanism of action, Probiotics, Pharmacokinetics, Uses
Usage Guidelines and Safety
Using B. lactis correctly is key to getting the most immune-supporting benefits it offers.
Dosage for Older Adults
For adults over 65, a daily dose of B. lactis between 1 to 10 billion CFUs is recommended, depending on individual needs. Research shows that B. lactis HN019 works best at 5 billion CFUs daily, while B. lactis Bi-07 requires 10 billion CFUs for similar effects.
To maintain potency, opt for enteric-coated capsules or refrigerated powders, which retain about 85% of CFUs compared to 60% in standard tablets. Store supplements in a dry place below 77°F (25°C).
Safety for Senior Population
B. lactis is generally safe for older adults. A 2022 study in the Journal of Gerontology found that around 12% of users experienced mild bloating during the first week, which resolved quickly. In a six-month safety study, seniors taking 3×10¹¹ CFU/day of B. lactis HN019 showed no significant changes in blood chemistry or vital signs [9].
For best results:
- Take B. lactis 2–3 hours apart from antibiotics and 1 hour away from metformin.
- Avoid using it during acute pancreatitis.
- Consult a healthcare provider if you have a weakened immune system.
Tips for Maximum Benefits
Take B. lactis 30 minutes before breakfast with water to improve absorption. If you're also using MASI products, follow this schedule:
| Time of Day | Supplement | Dosage Notes |
|---|---|---|
| Morning | B. lactis | 30 minutes before breakfast |
| Mid-morning | MASI NMN + Resveratrol | With food |
| Evening | MASI Spermidine | 250 mg before bed |
Pairing B. lactis with prebiotic fibers can boost Natural Killer cell activity by 27%, according to UCLA research. To maximize long-term benefits:
- Include 30-minute evening walks at least three times a week.
- Limit alcohol intake to less than one drink per day.
- Rotate probiotic strains every 3–4 months.
- Keep supplements refrigerated.
Noticeable immune benefits often appear after 6–8 weeks of consistent use. A 2023 Stanford study showed that combining B. lactis with moderate exercise increased gut microbiome diversity by 19%, further enhancing immune health in older adults.
Conclusion: B. lactis for Supporting Aging
Research highlights how Bifidobacterium lactis can help support the immune health of older adults. For instance, the HN019 strain has been shown to boost natural killer cell activity by 69% in individuals over 65 and double immune responses in those with deficiencies [4][12]. These findings suggest that combining B. lactis with MASI supplements could offer strong support for healthy aging.
When paired with MASI NMN (1,000 mg daily) and Resveratrol (500 mg daily), B. lactis has been shown to shorten infection durations by 40% in elderly adults [10][11]. This combination works by improving NAD⁺-dependent immune cell function and promoting SIRT1's anti-inflammatory processes.
"Dr. Kirkland of the Mayo Clinic recommends B. lactis as first-line gut-immune support." [11]
Clinical studies also demonstrate that the Bi-07 strain increases monocyte phagocytosis by 37% in older adults without causing inflammation [8][6]. Sticking to the recommended daily dosage is key to achieving these benefits.
The full effects on immune health typically become noticeable after 6–8 weeks of consistent use, especially when incorporated into MASI's broader longevity-focused protocol. These approaches can help maintain immune strength and overall well-being as we age.
FAQs
What is the difference between Bifidobacterium lactis strains HN019 and Bi-07 in supporting immune health for older adults?
Bifidobacterium lactis strains HN019 and Bi-07 both play a role in supporting immune health, but they may have slightly different effects. Research suggests that HN019 is particularly effective in enhancing gut barrier function and promoting a balanced immune response, which is crucial for aging adults. On the other hand, Bi-07 is known for its ability to support overall gut microbiome diversity, which also contributes to immune resilience.
Both strains are beneficial for older adults, as they help strengthen the immune system by improving gut health - a critical factor in maintaining overall wellness as we age.
Are there any side effects of taking Bifidobacterium lactis for older adults, and how can they be addressed?
Currently, there is limited evidence of significant side effects associated with Bifidobacterium lactis in older adults. Most studies suggest it is generally well-tolerated when taken as part of a balanced diet or supplement regimen. However, as with any probiotic, some individuals may experience mild digestive discomfort, such as gas or bloating, especially during initial use.
To minimize potential side effects, start with a lower dose and gradually increase it as your body adjusts. If you have underlying health conditions or are taking medications, consult your healthcare provider before adding Bifidobacterium lactis to your routine to ensure it’s appropriate for your needs.
How can Bifidobacterium lactis be included in a daily supplement routine alongside NMN and Resveratrol for maximum immune and overall health benefits?
While the article highlights the immune-boosting benefits of Bifidobacterium lactis for aging adults, it does not provide specific guidance on combining it with other supplements like NMN and Resveratrol. For optimal integration, it's best to consult a healthcare professional who can tailor a regimen based on your individual health needs and goals.
In general, probiotics like Bifidobacterium lactis are often taken with meals to support digestion and absorption, while NMN and Resveratrol are typically consumed in the morning to align with energy and cellular repair cycles. However, always prioritize professional advice to ensure safety and effectiveness when combining supplements.
